Development and characterization of a nanoemulsion. A new process to clean nanoparticles of platinum obtained by a waterinoil wo microemulsion without loss of crystalline structure was studied. A novel hydrogelthickened microemulsion of dapsone for acne treatment. How to clean them without loss of crystalline surface structure. A potential novel drug delivery system jaspreet kaur saini 1, ujjwal nautiyal 1, senthil kumar m 1, devendra singh 2, firoz anwar 3 1 department of pharmaceutics, himachal institute of pharmacy, paonta sahib, himachal pradesh, india. Dec 22, 2004 when sintered at 1150c, the microemulsion. Design and characterization of microemulsion systems for. Jul 02, 2011 formulation, characterization, and clinical evaluation of microemulsion containing clotrimazole for topical delivery fahima m. Pdf characterization of caco3 nanoparticles synthesized by. Synthesis and characterization of cds and cdse quantum dots. Formation and characterization of microemulsions containing. Effect of formulation components of microemulsion, trends in selection of new exicipients constituting oil phase, surfactant and cosurfactant has been highlighted herein.
Formulation and characterization of microemulsion system. Naproxen, microemulsion, phase diagram, characterization introduction microemulsions are macroscopically isotropic mixtures of at least a hydrophilic, a hydrophobic and an amphiphilic component. Thus, i would like to talk about what is emulsion, what are the main characteristics of emulsions, what are the existing methods for preparations of emulsions and how to make simple emulsions. Characterization and optimization of microemulsion and. Synthesis and characterization of silicacoated iron oxide. Ethanol cosurfactant is expected to disorder the interfacial film gave extended microemulsion zones by destabilizing the liquid crystalline phase. Microemulsion synthesis, characterization of highly. At 45% wtwt surfactant system, microemulsions containing various ratios of water and ipp were prepared and identified by electrical conductivity.
Preparation and characterization of oilinwater and waterin. This research was aimed to formulate and characterize a microemolsion systems as a topical delivery system of naproxen for relief of symptoms of rheumatoid. Characterization of microemulsions wiley online library. Pdf characterization of microemulsions prepared using isopropyl. Microemulsionbased approach for oral delivery of insulin. Apr 24, 2012 microemulsion synthesis, characterization of highly visible light responsive rare earth. Progress in microemulsion characterization sciencedirect. Since wo microemulsions would be most likely used to solubilize polar drugs, release of a hydrophilic drug from this model vehicle will be described in a later study. Index abbreviated hlk for the ratio water uptake capacity to oil uptake capacity has been proposed for the characterization of microemulsions. Formulation, characterization, and clinical evaluation of.
Naproxen, microemulsion, phase diagram, characterization. Very limited data are available to date on preparation of slns from prescreened microemulsion phase diagrams. Darunavir was a gift sample from mylan laboratories ltd, hyderabad, india. Behestimall l, shafaroodi h, jafariazar z, afshar m. The last two parts of book is devoted to discussion on different types of microemulsions applications, namely, use in drug delivery, vaccines, oil industry, preparation of nanostructured polymeric, metallic and metal oxides materials for different applications. Formulation and characterization of microemulsion based gel. Synthesis and characterization of cds and cdse quantum. The aqueous phase in microemulsion i was an aqueous solution 0. Review of nanoemulsion formulation and characterization.
Characterization of caco nanoparticles synthesized by. Prajapati, shailendra kumar, ajit singh, ankush singh institute of pharmacy, bundelkhand university, jhansi, uttar pradesh, india 284128. Research article microemulsion based approach for oral delivery of insulin. A microemulsion is basically characterized by analysing the phase behaviour of the system comprised of surfactant, cosurfactant, oil, and brine. Preparation, optimization and characterization of microemulsions. To investigate the effect of various surfactants and cosurfactants, and their ratio on microemulsions prepared with isopropyl palmitate ipp. Microemulsion was first introduced by hoar and schulman in 1943.
Aparna, prathima srinivas department of pharmaceutics, sri venkateshwara college of pharmacy, osmania university, madhapur, hyderabad500 081, andhra pradesh, india abstract. Kopera microemulsions are exciting systems that are promising as tuneable selfassembling templating reaction. Preparation and characterization of oilinwater and water. The microemulsion system is turning to be more viscous with addition of water and thus may help in the slow diffusing of drug at infinite dilution.
View the article pdf and any associated supplements and figures for a period of 48 hours. Research article optimization, characterization and in. Also, hexagonal and bicontinuous structures were seen in the sem photograph of the microemulsions. Development, characterization, and evaluation of celecoxib microemulsion for topical delivery. The drugloaded microemulsion optbercame showed better antibacterial activity against s. Design and characterization of microemulsion systems for naproxen. Effect of polyherbal microemulsion on staphylococcus. Improved method for solid lipid nanoparticle preparation. Microemulsion synthesis, characterization of highly visible light responsive rare earth. To improve the bioactivity and oral bioavailability of myricetin, a microemulsion formulation was successfully developed, which consisted of cremophor rh40 12%, tween 80 6%, transcutol hp 9%, wl 49 18%, and distilled water 55%. Capmul mcm, captex 200, captex 300 and captex 355 were gift. Characterization of microemulsion structures in the pseudoternary phase.
Characterization of microemulsion structures in the pseudoternary phase diagram of isopropyl palmitatewaterbrij 97. Pdf development and characterization of microemulsion based. Characterization of microemulsions prepared using isopropyl. Design, development and characterization of microemulsion. The process was optimized for the speed and time of stirring using ng microemulsion and results tabulated in table 5. The external phase was added in a drop wise manner under vortex mixing. Preparation and characterization of polystyrenesilver. Eskandar moghimipour, anayatollah salimi, soroosh eftekhari abstract purpose. A waterinoil microemulsion method has been applied for the preparation of silicacoated iron oxide nanoparticles. The process was optimized for the speed and time of stirring using ng microemulsion and results tabulated in. Represented simply, this involves generating oil, water and surfactant mixtures, and identifying compositions which form a single phase. To investigate the effect of various surfactants and cosurfactants, and their ratio on microemulsions prepared with isopropyl. The miotic activity was measured on albino rabbits. The ease of application and no requirement of extra energy input make the microemulsion method favorable for solid lipid nanoparticles slns production.
Abstract in the present work, levofloxacin based microemulsion was developed. Although ap was formulated in microemulsion, but the effectiveness of 1% of ap loaded ow microemulsion as an antioxidant was comparable to 1% solution of ap in methanol. Formulation, evaluation and characterization of periodontal microemulsion gel swaroopa. Bicontinuous and droplettype ow oilinwater microemulsions are formed depending.
Characterization and photocatalytic activity of n and pt doped titania prepared by microemulsion technique weinduo yang1, yichyun hsu2, wenchurng lin2 and ilun huang1 1department of chemical and materials engineering, national kaohsiung university of science and technology, taiwan. Development of clinical dosage forms for a poorly watera. Structural and optical characterization of zno nanoparticles. The globule size of microemulsion especially formulation c9 remained stable up to 60 days when stored at room temperature and after 6th cycle of freezethaw test. Feb 07, 20 naproxen is poorly water solubility and it is possible to increase its solubility by utilizing microemulsion systems.
Development and characterization of transdermal microemulsion gel for an antiviral drug brajesh kumar 1, sanjay kumar jain 1, sunil kumar prajapati 1, alok mahor 1 and ajay kumar 2 institute of pharmacy, bundelkhand university 1, jhansi up, india r. For example, employing higher temperature and including an additional salt in a microemulsion. School of chemistry and environment, south china normal university, guangzhou, china. Characterization of microemulsion structures in the pseudoternary. A potential novel drug delivery system jaspreet kaur saini 1, ujjwal nautiyal 1, senthil kumar m 1, devendra singh 2, firoz anwar 3 1department of pharmaceutics, himachal institute of pharmacy, paonta sahib, himachal pradesh, india. The rheological studies showed that microemulsions followed a newtonian. Various characterization techniques for nanoemulsions include determination of entrapment efficiency, particle size, polydispersity index, zeta potential as well as characterization through differential scanning calorimetry, fouriertransform infrared spectroscopy and transmission electron microscopy.
Microemulsion copolymerizations of methyl methacrylate. Phase behaviour and characterization of microemulsion. Microemulsion synthesis, characterization of highly visible. Characterization of caco3 nanoparticles synthesized by reverse microemulsion technique in different concentrations of surfactants. Pdf synthesis and characterization of cds nanoclusters. Definition and history one of the best definitions of microemulsions is from danielsson and lindman 1 a microemulsion is a system of water, oil and an amphiphile which is a single optically isotropic and thermodynamically stable liquid solution. Design and characterization of microemulsion systems for naproxen eskandar moghimipour 1, anayatollah salimi 1, soroosh eftekhari 2 1 nanotechnology research center, jundishapur university of medical sciences, ahvaz, iran. Department of materials science, national university of singapore, singapore 119260.
The developed buprenorphine loaded ow microemulsion was. Characterization of microemulsion structures in the. Electrochemical characterization of platinum nanoparticles prepared by microemulsion. Particle size of the optimized microemulsion formulation was found to be 40. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. Naproxen is poorly water solubility and it is possible to increase its solubility by utilizing microemulsion systems.
Pdf development, characterization, and evaluation of. Pdf on jan 1, 2011, vipin saini and others published development and characterization of microemulsion based system of aceclofenac find, read and cite. With lower content of surfactants and higher stability after dilution and storage for 6 months, the optimized myricetin microemulsion myrme could. A platform for improving dissolution rate of poorly water soluble drug surjyanarayan mandal and snigdha. Characterization and optimization of microemulsion and smedds. Formulation, evaluation and characterization of periodontal. Three different nonionic surfactants triton x100, igepal co520, and brij97 have been used for the preparation of microemulsions, and their effects on the particle size, crystallinity, and the magnetic properties have been studied. Paper open access extraction and characterization of. Mandal baroda college of pharmacy, vadodara, india. A pseudoternary phase diagram was constructed using water titration method. The results show the formation of a high surface area material sbet 96 m2 g1 constituted by homodispersed particles of a major pseudocubic.
We observed that the microemulsion area was wider at the phase diagram obtained with the higher purity lecithin. Method, characterization and applications akanksha garud, deepti singh, navneet garud department of pharmaceutics, institute of professional studies, college of pharmacy, gwalior, madhya pradesh 474002, india introduction targeted delivery of a drug molecule to specific. We found that the extent of the microemulsion region depended upon both the purity of the lecithin and the surfactantcosurfactant scos mixing ratios k m. Experimental and molecular dynamics characterization of. Preparation and characterization of microemulsions of. Microemulsion based gel has been increased interest during recent years in the use of topical vehicle systems that could modify drug permeation through the skin. Microemulsion science has relied heavily on characterization techniques, both from the perspective of fundamental elucidation of phase and nanostructural behavior, as well as through identifying the unique properties which make them fit for function in the applications mentioned above. Characterization of me according to the regions obtained for ow me in the phase. Synthesis and characterization of cds and cdse quantum dots by uvvis spectroscopy ekpekpo arthur and akpojivi lucky department of physics, delta state university abraka, nigeria. The microemulsion system thus, shows a structural change from oil continuous system to water continuous, which has higher viscosities than the former 34. A novel hydrogelthickened microemulsion of dapsone for. The optimized microemulsion formulation was characterized for its refractive index, % transmittance, ph, viscosity, drug content and particle size. The research interest is preparation and characterization of oilinwater and waterinoil emulsions.
Based on the microemulsion areas produced in the pseudoternary phase diagrams, the the. This research was aimed to characterize microemulsion systems of isopropyl palmitate ipp, water, and 2. Method, characterization and applications akanksha garud, deepti singh, navneet garud department of pharmaceutics, institute of professional studies, college of pharmacy, gwalior, madhya pradesh 474002, india introduction targeted delivery of. Largest microemulsion single phase region was found at s mix 2. Pdf on jan 1, 2011, vipin saini and others published development and characterization of microemulsion based system of aceclofenac find, read and cite all the research you need on researchgate. One of the most promising techniques for enhancement of transdermal permeation of drugs is microemulsion. Structural and optical characterization of zno nanoparticles synthesized by microemulsion route harish kumar, renu rani department of chemistry, chaudhary devi lal university, sirsa 125 055 haryana, india fax.
A prolonged pilocarpine release from the microemulsions with lecithin was shown in in vitro experiments. The oil phase, surfactant and cosurfactant were selected on the basis of their. Preparation and characterization of polystyrenesilver nanocompositeusing microemulsionmethod and its antibacterial activity alireza asalabat, farid bmirhoseinia, zahra masoumia, majid mahdie a department of chemistry, faculty of science, arak university, 38156 8 8349, arak, iran. The phase behaviour of microemulsion can alter from winsor type i to winsor type ii through winsor type iii by adjusting the salinity at. Physical characterization and stability of a microemulsion for. To achieve this, buprenorphine solubility was tested in various vehicles and vehicles with highest solubility for buprenorphine were selected as components oils, surfactants and cosurfactants of microemulsion.
The classical starting point for microemulsion characterization is the ternary phase diagram shown in fig. Research article optimization, characterization and in vitro. Pdf development and characterization of microemulsion. Synthesis and characterization of cds nanoclusters in a quaternary microemulsion. The advantages of this solid microemulsion precondoi 10.
Preparation, optimization and characterization of microemulsions 170 titrated with the continuous phase. Paper open access extraction and characterization of crude. The aim of the present study was to design novel ow microemulsion of glimepiride and to study its. Formulation and physical characterization of microemulsions based carboxymethyl cellulose as vitamin c carrier 278 results and discussion characterization of carboxymethyl cellulose the ir spectra of both samples cellulose and its derivative carboxymethyl cellulose cmc are shown as in fig. Over the past few years, much attention has been paid to potential pharmaceutical uses of microemulsions as novel drug delivery systems. Pdf characterization of caco3 nanoparticles synthesized. View the article pdf and any associated supplements and figures for a. Ce with conventional uv detection has recently been shown as a highly effective means to assaying cytotoxic galliumiiibased compounds with regard to desirable druglike properties such as the stability and binding to serum proteins. The aim of the present study was to make a comparison of the in vitro release rate of diclofenac sodium ds from microemulsion m vehicles containing soybean oil, nonionic surfactants brij 58 and span 80, and different alcohols ethanol e, isopropyl alcohol i, and propanol p as cosurfactant. Formulation and characterization of microemulsion system essay abstraction. Shaker, mohamed khalid ghorab, mohamed nasr, and aliaa ismail. Development and characterization of microemulsions for ocular. Development, characterization, physicochemical stability and ex vivo permeation studies. The mixtures were observed against a dark background after illuminating the samples with white light.
Characterization and photocatalytic activity of n and pt. Formulation of a new oilinwater ow microemulsion composed of castor oiltween 80ethanolphosphate buffer for heightening the lading capacity of an antiinflammatory drug feldene has been accomplished. Experimental materials used for the phase behavior characterization, and. The aim of the present study was to develop an ow microemulsion for poorly solubilized potent semisynthetic opiate analgesic drug buprenorphine for sublingual administration. Rani, structural and optical characterization of zno nanoparticles synthesized by microemulsion route, international letters of chemistry, physics and astronomy, vol. Pseudoternary phase diagram was used to define the microemulsion area, and samples from the best combinations, i. Also, me6 may be preferable for topical naproxen formulation. Microemulsion characterization has been performed by phase. Various adsorbents were incorporated in the optimized liquid microemulsion to get solid microemulsion.
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